President: I need something megabig, for my legacy. Like the War On Drugs, War Against Cancer, War On Terror...
Advisor (in a whispered aside): Does he know we aren't winning those? (Out loud) The Apollo moon shot project, sir? Mapping the human genome?
President: Exactly. One of them. Or one like them. I want the biggest thing ever. What's the greatest mystery of all?
Advisor 2: God, sir.
President: We can't solve God. It says so in the Bible.
Advisor 3: Women?
President: Good one. "The Human Women Project." Wait, women might not like being seen as a problem to be solved, even though they are, hey fellers? And they have the vote, so no.
Advisor 2: The Greatest Mystery Of All is...The Yooman Brane!
President: I love it! The Human Brainome Project! My legacy is secure! Get someone at NIH on to it, will you?
(The answer is 42.)